The 1992 Monaco Grand Prix (formally the 50ème Grand Prix de Monaco) was a Formula 1 motor race held on 31 May 1992 at the Circuit de Monaco. It was the sixth race of the 1992 Formula One World Championship.

The 78-lap race was won by Ayrton Senna, driving a McLaren-Honda. Drivers' Championship leader Nigel Mansell took pole position in his Williams-Renault and led until lap 71, when he suspected he had a puncture and made a pit stop for new tires. He emerged behind Senna, closed up to the Brazilian and tried to find a way past but without success, Senna holding on to win by 0.2 seconds. It was Senna's fifth Monaco Grand Prix win, equaling the record set by Graham Hill.

Mansell's teammate Riccardo Patrese was third, half a minute behind, with the top six completed by the Benettons of Michael Schumacher and Martin Brundle and the Larrousse of Bertrand Gachot.

Original race-used wheel nut, framed and hand-signed on the display glass by Senna in black marker.